People who have Arthritis report that their symptoms have decreased after taking an Nrf2 activator. Following the testimonials are current research articles that report new information about the cause of Arthritis and how Nrf2 activators can be effective in treating it at the cellular level where it starts.
"My chiropractor asked me to try Protandim. He didn't tell me a whole lot about it except the science behind it at first, and he didn't tell me what to expect. He just said he wanted to see what would happen. I started taking it. Five days later I woke up to find I had slept nine and a half hours. It was the first time I had done that in a long time. I woke up feeling pretty refreshed. Normally I wake up spending hours in a fog. That was just amazing to me. On day eleven I noticed my knuckles weren't swollen and red any more, and my hands didn't hurt, and I noticed that my knees hadn't been hurting like they used to, and my elbows didn't hurt.
"On day 31 I found that I was sleeping seven and a half hours a night. When I wake up I don't feel like I'm in a fog. I feel great. All during the day things seem to be clearer. A wrist that I broke when I was 14 years old used to pop and crack and snap. Well, it doesn't make a sound anymore, and it doesn't hurt to move it. On day 36 I noticed that I had dropped a few pounds. When I started off I was 195 pounds. On day 36 I was at 182. I am 6 foot tall. The 182 put me right in the center of the BMI for normal weight, where before I was overweight. I think I had been in a bit of depression also. On day 36 I noticed also things were brighter, I feel better, and I'm positive I was in a depression before. My joints no longer hurt and ache. I can walk up the stairs just fine. My pain level was a 3 to a 6 every day. Now it's a 0 or a one. I feel fantastic. I haven't felt this good for years.
"On day 42 I noticed that my skin is softer. The backs of my hands don't have the old age wrinkles like I used to. On day 56 I was driving home late at night and noticed that headlights weren't bothering me. I have pretty bad astigmatism, and that is what my doctor said gave me the problem of seeing stars and halos around headlights at night. Then looking back at the road it was hard to refocus on what was ahead of me. So I didn't drive at night usually. That night the headlights looked clear so it was much easier to drive at night. My vision is clearer, especially at night." (See him tell the story)
"He said, Harold, I don't know what I'm going to do with you. He says we just got the lab work back, and according to the lab your kidneys are functioning the same as an 18 or 19 year old. For an 81 year old man that's quite a difference there. He said your liver and all your organs inside are just like a young man. I said doctor, you know what's causing that don't you? He said after reading the material about Protandim, it's got to be that. He said nothing else I know of could slow down the aging process in a person like this has done for you. So it's just amazing, and I'll tell you I'm going to stay on it for the rest of my life." youtube.com, search "Protandim"
Clarice (age 82): “For many years the base of my thumb(s) has been swollen from arthritis. Each year it has worsened. When Vivix came out I was skeptical, but I had so much pain in my thumb that I was willing to try anything. After on Vivix only three days I was absolutely amazed. I live with my daughter and I couldn’t wait to show her my thumbs. We stared together, in absolute awe, as the swelling was gone – and the pain was substantially less!
I also had hip pain. That didn’t go away quite as quickly. The pain was so terrible that walking more than 20 steps at a time was prohibitive. Yet within two weeks of being on Vivix it began to improve. And now, after about six weeks, I have very little hip pain at all. I can do something I haven’t been able to do for a long time – take my dog for a walk all the way around the block. This would be enough to keep me on my Vivix, but I have noticed another wonderful thing has happened.
I have Reynaud’s Syndrome. This is a condition in which the smallest arteries that bring blood to the fingers or toes constrict (go into spasm). One of the triggers, and the one that affects me, is the cold. Even entering a cold grocery store can cause my fingers to go white, or even turn blue. It is very uncomfortable and often I have to wear gloves where other people wouldn’t. Wintertime is always a concern for me. Not so this year! Not only have I needed gloves incredibly less often than usual, BUT I have had no episodes of my fingers turning white. I can only attribute it to Vivix, and it is wonderful!” (http://jswank.myhomebizniz.com/)
RESEARCH ARTICLE (from pubmed.gov):
Int Immunopharmacol. 2015 Jan 16;25(1):74-82. doi: 10.1016/j.intimp.2015.01.005. [Epub ahead of print]Fibroblast growth factor 21 (FGF21) ameliorates collagen-induced arthritis through modulating oxidative stress and suppressing nuclear factor-kappa B pathway. Author information Abstract
It has been demonstrated that circulating FGF21 levels are elevated in the serum and synovial fluid of patients with rheumatoid arthritis (RA). The aim of this study is to investigate efficacy of FGF21 for treatment of RA and the molecular mechanisms of the therapeutic effect on collagen-induced arthritis (CIA). Mice with CIA were subcutaneously administered with FGF21 (5, 2 or 1mg·kg-1·d-1), IL-1β antibody (5mg·kg-1·d-1), IL-17A antibody (5mg·kg-1·d-1) and dexamethasone (DEX) (1mg·kg-1·d-1), respectively. The effects of treatment were determined by arthritis severity score, histological damage and cytokine production. The activation of NF-κB was analyzed by Western blotting. We also detected the levels of oxidative stress parameters. Our results showed that FGF21 had beneficial effects on clinical symptom and histological lesion of CIA mice. Similar to antibody and DEX, FGF21 treatment alleviated the severity of arthritis by reducing humoral and cellular immune responses and down-regulating the expression of pro-inflammatory cytokines. FGF21 treatment also reduced the expression of TNF-α, IL-1β, IL-6, IFN-γ and MMP-3 and increased level of IL-10 in the spleen tissue or the plasma of CIA mice in a dose-dependent manner. Furthermore, FGF21 inhibited IκBα degradation and NF-κB p65 nuclear translocation and induced significant changes of oxidative stress parameters (MDA, SOD, CAT, GSH-PX and GSH) in the plasma. FGF21 exerts therapeutic efficacy for RA through antioxidant reaction and inhibiting NF-κB inflammatory pathway. This study provides evidence that FGF21 may be a promising therapeutic agent for RA patients.
Copyright © 2015 Elsevier B.V. All rights reserved.
PMID: 25601498 [PubMed - as supplied by publisher]
[INTERPRETATION: Arthritis is improved by FGF21 because it reduces inflammation and oxidative stress (cell damage by free radicals). The new therapy for arthritis is to increase the body’s antioxidants and stopping inflammation.]