Andrographolide is a Nrf2 activator.  Users of Nrf2 activators report positive experiences.

Andrographolide is a drug.  As such, it is marketed as a treatment that uses the Nrf2 pathway to bring about positive results.  It is available at and

However, no product reviews or testimonials were found on this drug.

RESEARCH ARTICLES (from  As of March 2015, there were 505 references to this drug in studies.  Following are some of the most recent ones, all showing positive effects of this Nrf2 activator, especially for diabetes, cancer, retinopathy, asthma, cognitive impairments, and cell repair after E-coli damage.


Br J Pharmacol. 2015 Feb 25. doi: 10.1111/bph.13118. [Epub ahead of print]

Andrographolide derivative AL-1 improves insulin resistance through down-regulation of NF-κB signaling pathway.



Andrographolide is the most active constituent of the medicinal plant Andrographis paniculata. Previously, we synthesized a novel andrographolide derivative AL-1, conjugating andrographolide with lipoic acid. Although the antioxidative and/or anti-inflammatory activity of AL-1 contributes to its cytoprotective effects, whether AL-1 can improve insulin resistance and the underlying mechanisms remain largely unknown.


We investigated the anti-hyperlipidemic and anti-hyperglycemic effects of AL-1 on high fat diet-fed/STZ-induced animal diabetic model. In addition, we investigated the effect of AL-1 on NF-κB signaling pathway in RIN-m cells with a focus on the link between ROS-associated inflammation and insulin resistance.


AL-1 had significant hypoglycemic effect at the doses of 40 and 80 mg/kg, and which could significantly reduce the level of cholesterol and increased high-density lipoprotein. AL-1 reduced homeostasis model assessment of insulin resistance (HOMA-IR) and enhanced insulin sensitivity. In addition, AL-1 improved the morphology of pancreatic islet and their function. Furthermore, AL-1 suppressed high glucose-induced phosphorylation of the p65 and IκBα in RIN-m cells.


AL-1 had the hypoglycemic effect and improved insulin resistance in type 2 diabetic rats. It prevented islet from high glucose-induced oxidative damage via the down-regulation of NF-κB signaling pathway. Further investigation of AL-1 as a promising new agent for treatment and/or prevention of diabetes are warranted.

This article is protected by copyright. All rights reserved.

PMID:  25712508  [PubMed - as supplied by publisher]

[INTERPRETATION:  AL-1 is a derivative of Andrographolide.  It has proven useful as an antioxidant, anti-inflammatory, and cell protector.  It significantly reduces cholesterol, improves function of the pancreas, improves insulin resistance in diabetics, and prevents cell damage from the high glucose that causes oxidants.  This is a good new treatment for diabetes.]

Andrographolide inhibits hypoxia-inducible factor-1 through phosphatidylinositol 3-kinase/AKT pathway and suppresses breast cancer growth.

Li J, Zhang C, Jiang H, Cheng J.

Onco Targets Ther. 2015 Feb 13;8:427-35. doi: 10.2147/OTT.S76116. eCollection 2015.


Separation of five compounds from leaves of Andrographis paniculata (Burm. f.) Nees by off-line two-dimensional high-speed counter-current chromatography combined with gradient and recycling elution.

Zhang L, Liu Q, Yu J, Zeng H, Jiang S, Chen X.

J Sep Sci. 2015 Feb 13. doi: 10.1002/jssc.201401458. [Epub ahead of print]


New flavonoid glycosides and other chemical constituents from Clerodendrum phlomidis leaves: isolation and characterisation.

Bharitkar YP, Hazra A, Shah S, Saha S, Matoori AK, Mondal NB.

Nat Prod Res. 2015 Feb 12:1-7. [Epub ahead of print]


Study on Pharmacokinetics of Three Preparations from Levistolide A by LC-MS-MS.

He WQ, Lv WS, Zhang Y, Qu Z, Wei RR, Zhang L, Liu CH, Zhou XX, Li WR, Huang XT, Wang Q.

J Chromatogr Sci. 2015 Feb 5. pii: bmu224. [Epub ahead of print]


Ameliorative effect of certain antioxidants against mercury induced genotoxicity in peripheral blood lymphocytes.

Patel TA, Rao MV.

Drug Chem Toxicol. 2015 Feb 3:1-7. [Epub ahead of print]

Andrographolide ameliorates diabetic retinopathy by inhibiting retinal angiogenesis and inflammation.

Yu Z, Lu B, Sheng Y, Zhou L, Ji L, Wang Z.

Biochim Biophys Acta. 2015 Apr;1850(4):824-31. doi: 10.1016/j.bbagen.2015.01.014. Epub 2015 Jan 29.


Specificity and Inhibitory Mechanism of Andrographolide and Its Analogues as Antiasthma Agents on NF-κB p50.

Nguyen VS, Loh XY, Wijaya H, Wang J, Lin Q, Lam Y, Wong WS, Mok YK.

J Nat Prod. 2015 Feb 27;78(2):208-17. doi: 10.1021/np5007179. Epub 2015 Jan 23.


SRS06, a New Semisynthetic Andrographolide Derivative with Improved Anticancer Potency and Selectivity, Inhibits Nuclear Factor-κB Nuclear Binding in the A549 Non-Small Cell Lung Cancer Cell Line.

Lim JC, Jeyaraj EJ, Sagineedu SR, Wong WS, Stanslas J.

Pharmacology. 2015;95(1-2):70-7. doi: 10.1159/000370313. Epub 2015 Jan 23.


Andrographolide decreased VEGFD expression in hepatoma cancer cells by inducing ubiquitin/proteasome-mediated cFos protein degradation.

Ji L, Zheng Z, Shi L, Huang Y, Lu B, Wang Z.

Biochim Biophys Acta. 2015 Apr;1850(4):750-8. doi: 10.1016/j.bbagen.2015.01.005. Epub 2015 Jan 14.


Andrographolide and analogues in cancer prevention.

Mishra SK, Tripathi S, Shukla A, Oh SH, Kim HM.

Front Biosci (Elite Ed). 2015 Jan 1;7:255-66.


Andrographolide inhibits proliferation of human lung cancer cells and the related mechanisms.

Luo X, Luo W, Lin C, Zhang L, Li Y.

Int J Clin Exp Med. 2014 Nov 15;7(11):4220-5. eCollection 2014.


Andrographolide reduces cognitive impairment in young and mature AbetaPPswe/PS-1 mice.

Serrano FG, Tapia-Rojas C, Carvajal FJ, Hancke J, Cerpa W, Inestrosa NC.

Mol Neurodegener. 2014 Dec 18;9(1):61. [Epub ahead of print]


[Effect of andrographolide on Candida albicans biofilm dispersion].

Shi GX, Yan YY, Shao J, Lu KQ, Zhang MX, Wang TM, Wang CZ.

Zhongguo Zhong Yao Za Zhi. 2014 Sep;39(17):3339-43. Chinese.


[Characteristic fingerprint analysis and determination of main components on Andrographis paniculata extract by UPLC].

Zhang HY, Xu XF, Huang Y, Wamg DQ, Deng QH.

Zhong Yao Cai. 2014 Jun;37(6):1055-8. Chinese.


[Effect of andrographolide derivative Yanhuning on in vivo Candida albicans biofilms in rats].

Shi GX, Yan YY, Shao J, Zhang MX, Lu KQ, Wang TM, Wang CZ.

Zhongguo Zhong Yao Za Zhi. 2014 Aug;39(15):2924-9. Chinese.


Synthesis and anticancer activity of some novel indolo[3,2-b]andrographolide derivatives as apoptosis-inducing agents.

Song Y, Xin Z, Wan Y, Li J, Ye B, Xue X.

Eur J Med Chem. 2015 Jan 27;90:695-706. doi: 10.1016/j.ejmech.2014.12.017. Epub 2014 Dec 11.


Cytochrome P450 induction properties of food and herbal-derived compounds using a novel multiplex RT-qPCR in vitro assay, a drug-food interaction prediction tool.

Koe XF, Tengku Muhammad TS, Chong AS, Wahab HA, Tan ML.

Food Sci Nutr. 2014 Sep;2(5):500-20. doi: 10.1002/fsn3.122. Epub 2014 Jun 10.

[Characteristic fingerprint analysis and determination of main components on Andrographis paniculata extract by UPLC].

Zhang HY, Xu XF, Huang Y, Wamg DQ, Deng QH.

Zhong Yao Cai. 2014 Jun;37(6):1055-8. Chinese.


Andrographolide interferes quorum sensing to reduce cell damage caused by avian pathogenic Escherichia coli.

Guo X, Zhang LY, Wu SC, Xia F, Fu YX, Wu YL, Leng CQ, Yi PF, Shen HQ, Wei XB, Fu BD.

Vet Microbiol. 2014 Dec 5;174(3-4):496-503. doi: 10.1016/j.vetmic.2014.09.021. Epub 2014 Oct 5.