People who have ADD report that their symptoms have decreased after taking an Nrf2 activator.  Following the testimonials are current research articles that report new information about the cause of ADD and how Nrf2 activators can be effective in treating it at the cellular level where it starts.

Nancy Levitt:  "I suffered from ADD, Joint Pain and Skin Cancer. I had real achy joints from teaching aerobics for so many years, and after just a few weeks of using Protandim, that subsided immediately. I was also using some anxiety medication. I noticed that all my symptoms from anxiety went away, so my doctor weaned me off that medication. I feel very calm, very focused.  I no longer struggle with ADD, and joint pain is gone."  (

Deborah Merlin:  Deborah's twin sons were born prematurely.  By age 3 they were diagnosed with speech delays, Autism/Asperger's Syndrome, ADD with hyperactivity (ADHD), gross motor and fine motor delays, chronic ear infections, asthma, and multiple food allergies.  One had visual tics, violent behavior, no impulse control, and seizures. The twins were prescribed drugs, but the drugs only suppressed the symptoms and didn't cure.  With diet modifications (removing milk), there was no more ear fluid, so they could hear, and the autism-like symptoms went away.  Testing showed they were low in amino acids.  With amino acid supplements, the one's facial tics stopped, the violent behavior went away, the seizures stopped, the child was happier, and he went from failing to getting As and Bs in school.  This mom is a big proponent in natural supplements to treat neurological problems in children.  See her tell the story.  

Susan Stephens: Began using Vivix Saturday morning and by Monday noticed a marked improvement in my ability to focus on one task at a time through the day. This has always been an issue for me; beginning one thing after another and having difficulty completing any. Even with using Mental Acuity Plus, I still had some degree of difficulty. I'm absolutely amazed that I've been so clear-headed, focused and energeticthis week. Vive Vivix!!!    Go to source.
Andy Gulick: Well, I am 60 and I don't have any sense of feeling any different either. But, I work out and race-walk. I've become a seasonal walker and no longer walk during the winter months like I used to. But in August to September, after being on the Vivix 2.5 weeks, I cut my time for a 5K (3.15 mi.) walk by about 6 minutes faster. And, when I was walking the slower time I was really pushing and it felt hard going up hills. I walked it after being on Vivix for 2.5 weeks and got a much faster time, it seemed effortless compared to before I was taking Vivix and I still walked it 6 minutes faster. (a time I was walking around 12 years ago) Vivix works at the cellular level and just as a nineteen year old is aging at the cellular level, he doesn't feel the aging taking place because it is at the cellular level. In the same way, since the slowing of the aging process is at the cellular level, you won't "FEEL" it working unless you have some test such as an aerobic workout, or something for your body to repair. I also have ADD and I've noticed that I am remembering some things more often than before taking it. I still have ADD, but my mental acuity has moved up a notch or two.    Go to source.


Redox Rep. 2016 Feb 18:1-6. [Epub ahead of print]
Increased oxidative stress in children with attention deficit hyperactivity disorder.

The purpose of this study was to investigate oxidative stress in children with attention deficit hyperactivitydisorder (ADHD).


Total oxidant status (TOS), total antioxidant status (TAS), paraxonase-1 (PON-1) and arylesterase (ARE) activity were measured in 76 children (44 boys, 32 girls) diagnosed with ADHD according to the DSM-IV and 78 healthy children (46 boys, 32 girls).


Age and sex were similar between the groups (P > 0.05). TOS and the oxidative stress index (OSI) were higher in the patient group than the control group (P < 0.001). PON-1 (P = 0.002), ARE (P = 0.010) activity and TAS (P < 0.001) were lower in the patient group than the control group.


We found decreased PON-1, ARE activity and TAS, and increased TOS and OSI in children with ADHD. Our study showed that there is significantly increased oxidative stress in children with ADHD.

PMID: 26886057 

[INTERPRETATION:  Kids with ADHD were found to have higher levels of oxidants and much higher oxidative stress (cell damage by free radicals).  They have fewer antioxidants in their bodies.]  


Psychiatry Investig. 2015 Jul;12(3):361-6. doi: 10.4306/pi.2015.12.3.361. Epub 2015 Jul 6.
Evaluation of Oxidative Metabolism in Child and Adolescent Patients with Attention DeficitHyperactivity Disorder.

Oxidative metabolism is impaired in several medical conditions including psychiatric disorders, and this imbalance may be involved in the etiology of these diseases. The present study evaluated oxidative balance in pediatric and adolescent patients with attention deficit hyperactivity disorder (ADHD).


The study included 48 children and adolescents (34 male, 14 female) with ADHD who had no neurological, systemic, or comorbid psychiatric disorders, with the exception of oppositional defiant disorder (ODD), and 24 sex- and age-matched healthy controls (17 male and seven female).


TAS was significantly lower, and TOS and OSI were significantly higher in patients with ADHD than in healthy controls. Total antioxidant levels were lower in patients with comorbid ODD than in those with no comorbidity. No difference was found in TOS or OSI among the ADHD subtypes; however, TAS was higher in the attention-deficient subtype.


Our findings demonstrated that oxidative balance is impaired and oxidative stress is increased in children and adolescents with ADHD. This results are consistent with those of previous studies.

PMID: 26207130 

[INTERPRETATION:  Oxidative stress is involved in, and probably the cause of, psychiatric disorders like ADHD.  Results show that oxidative stress (cell damage by free radicals) is much higher in people who have ADHD.  Studies done before this one have had the same results, showing over and over that oxidative stress is strongly linked to ADHD.]


Psychiatry Res. 2015 Sep 30;229(1-2):310-7. doi: 10.1016/j.psychres.2015.07.003. Epub 2015 Jul 8.
Attention Deficit Hyperactivity Disorder and oxidative stress: A short term follow up study.

In this study, we aimed to investigate total antioxidative status (TAS) and total oxidative status (TOS) of plasma and antioxidant enzymes such as paraoxonase (PON), stimulated paraoxonase (SPON), arylesterase (ARES) and thiols in plasma of children and adolescents with Attention Deficit Hyperactivity Disorder (ADHD). In the second step. this study aimed to reveal the possible effects of ADHD treatment on these parameters. Fifty-six patients with ADHD and 52 healthy controls were involved in this study. Venous blood samples were collected and oxidative and antioxidative parameter's were studied. In the second phase of the study, blood samples were taken from patients using medication. Pre-treatment oxidative stress index (OSI) values and the plasma TOS levels of the patients with ADHD were statistically higher than those of the control group. The plasma thiol levels of the patients with ADHD were significantly lower than the control group. The post-treatment plasma antioxidative parameter's levels were significantly higher than the pre-treatment levels. The post-treatment oxidative stress index value was significantly lower than the pre-treatment value. Therefore, oxidative metabolism was found to be impaired in children and adolescents with ADHD. It was also determined that methylphenidate repairs the oxidative balance by increasing antioxidant defence mechanisms.

PMID: 26188640 

[INTERPRETATION:  People with ADHD have much higher levels of oxidative stress (cell destruction by free radicals) than those without ADHD.  After taking a drug that stimulates the body's production of its own antioxidant defenses, the oxidative stress was reduced to balanced levels.]  There are many natural substitutes to drugs, including certain foods and supplements like Protandim, Asea, Nrf2 Stimulator, etc.
Oxid Med Cell Longev. 2015;2015:248529. doi: 10.1155/2015/248529. Epub 2015 Jun 9.
Psychiatric Disorders and Polyphenols: Can They Be Helpful in Therapy?

The prevalence of psychiatric disorders permanently increases. Polyphenolic compounds can be involved in modulation of mental health including brain plasticity, behaviour, mood, depression, and cognition. In addition to their antioxidant ability other biomodulating properties have been observed. In the pathogenesis of depression disturbance in neurotransmitters, increased inflammatory processes, defects in neurogenesis and synaptic plasticity, mitochondrial dysfunction, and redox imbalance are observed. Ginkgo biloba, green tea, and Quercus robur extracts and curcumin can affect neuronal system in depressive patients. ADHD patients treated with antipsychotic drugs, especially stimulants, report significant adverse effects; therefore, an alternative treatment is searched for. An extract from Ginkgo biloba and from Pinus pinaster bark, Pycnogenol, could become promising complementary supplements in ADHD treatment. Schizophrenia is a devastating mental disorder, with oxidative stress involved in its pathophysiology. The direct interference of polyphenols with schizophrenia pathophysiology has not been reported yet. However, increased oxidative stress caused by haloperidol was inhibited ex vivo by different polyphenols. Curcumin, extract from green tea and from Ginkgo biloba, may have benefits on serious side effects associated with administration of neuroleptics to patients suffering from schizophrenia. Polyphenols in the diet have the potential to become medicaments in the field of mental health after a thorough study of their mechanism of action.

PMID: 26180581

[INTERPRETATION:  People who have psychiatric disorders such as ADHD have an imbalance of oxidants to antioxidants, causing oxidative stress (damage of cells by free radicals).  People with ADHD can be treated with foods containing polyphenols, which have been shown to improve behavior, mood, and cognition.  Polyphenols inhibit oxidative stress.  Since drugs have so many bad side effects, the new treatment is going to be polyphenols, which are simply the ingredients in some common foods, without the undesirable side effects.]
NOTE: Polyphenols are Nrf2 activators.  The best examples are fruits and vegetables, although they also occur in green tea, black tea, red wine, coffee, chocolate, olives, extra virgin olive oil, herbs and spices, nuts, legumes, and cereals.


Brain Connect. 2015 Jan 20.

Shared Brain Connectivity Issues, Symptoms, and Comorbidities in Autism Spectrum Disorder, Attention Deficit/Hyperactivity Disorder, and Tourette Syndrome.

The prevalence of neurodevelopmental disorders, including autism spectrum disorder (ASD), attention deficit/hyperactivity disorder (ADHD), and Tourette syndrome (TS), has increased over the past two decades. Currently, about 1 in 6 children in the United States is diagnosed with a neurodevelopmental disorder. Evidence suggests that ASD, ADHD, and TS have similar neuropathology, which includes long-range under-connectivity and short-range over-connectivity. They also share similar symptomatology, with considerable overlap in their core and associated symptoms and a frequent overlap in their comorbid conditions. Consequently, it is apparent that ASD, ADHD, and TS diagnoses belong to a broader spectrum of neurodevelopmental illness. Biologically, long-range under-connectivity and short-range over-connectivity are plausibly related to neuronal insult (e.g., neurotoxicity, neuroinflammation, excitotoxicity, sustained microglial activation, proinflammatory cytokines, toxic exposure, oxidative stress, etc.). Therefore, these disorders may a share a similar etiology. The main purpose of this review is to critically examine the evidence that ASD, ADHD, and TS belong to a broader spectrum of neurodevelopmental illness, an abnormal connectivity spectrum disorder (ACSD), which results from neural long-range under-connectivity and short-range over-connectivity. The review also discusses the possible reasons for these neuropathological connectivity findings. In addition, this review examines the role and issue of axonal injury and regeneration in order to better understand the neuropathophysiological interplay between short- and long-range axons in connectivity issues.

PMID:  25602622  [PubMed - as supplied by publisher]

[INTERPRETATION:  ADHD is caused by nervous system problems like inflammation, toxins, and oxidative stress (cell damage by free radicals).  So are some other problems like autism and Tourette’s.]